be mediated by E- and P-selectin binding to carbohydrate. Acute inflammation is PMNL versus monocyte recruitment was the observation that while optimal

P-Selectin cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each P-Selectin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.

E-selectin is not expressed under baseline conditions, except in skin microvessels, but is rapidly induced by inflammatory cytokines. During P- and E-selectin-mediated migration of Tc1 cells, P-selectin glycoprotein ligand-1 appears to be the sole ligand for P-selectin and one of the ligands for E-selectin. P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. The three selectins, E-selectin (CD62E), L-selectin (CD62L) and P-selectin (CD62P), are related both structurally and functionally. They have been extensively studied due to their role in the inflammatory response and their potential use as therapeutic targets. E-selectin, also known as CD62 antigen-like family member E, endothelial-leukocyte adhesion molecule 1, or leukocyte-endothelial cell adhesion molecule 2, is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation.

New!!: P-selectin and Crizanlizumab · See more » Deep vein thrombosis. Deep vein thrombosis (DVT), is the formation of a blood clot in a deep vein, most commonly P-sélectine Indeed, P - selectin variants were considered as likely candidates as possible alloantigens. En effet, certaines variantes de la P - sélectine sont considérées comme des alloantigènes potentiels. 2008-11-25 · P-selectin. Alternative name(s): CD62 antigen-like family member P. Granule membrane protein 140. Short name: GMP-140 1 Publication The selectin family members, L-Selectin, P-Selectin, and E-Selectin, are involved in the adhesion of leukocytes to activated endothelium. This adhesion is 2b) (P < 0.05 versus LPS-Gal plus PBS, n = 7 to 9).

E- and P-selectin: differences, similarities and implications for the design of P-selectin antagonists. Binder FP (1), Ernst B. Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising

1 Definition. P-Selektin ist ein Protein, das als Zelladhäsionsmolekül (CAM) auf den Oberflächen von aktivierten Endothelzellen und Thrombozyten fungiert. In inaktiven Endothelzellen wird es in Zellgranula gespeichert, die Weibel-Palade-Körperchen genannt werden, in inaktiven Thrombozyten in den α-Granula . E-selectin is a vascular adhesion molecule expressed mainly on endothelium, and its primary role is to facilitate leukocyte cell trafficking by recognizing ligand surface proteins.

Similarly to cell-surface P-selectin, E-selectin is rapidly down- regulated by internalization and degradation in lysosomes; however, the intracellular targeting mechanism of E-selectin is still unknown (63,72).

P-selectin acts as a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin-mediated adhesive interactions operate in conjunction with cell-cell interactions directed by related molecules and are likely to be important in both hemostatic and inflammatory processes.

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Recent findings PSGL-1 was originally described as a leukocyte ligand for P-selectin, but it is actually a ligand for all selectins (P-, L- and E-selectin), binds chemokines, activates integrins and profoundly affects T-cell biology P-selectin havas funkcian rolon en metastazo de tumoro simila al E-selectin. [16] P-selectin estas esprimita sur la surfaco de same stimulis endotelan ĉelon kaj aktivtrombociton kaj helpas al kanceraj ĉeloj invadi en sangocirkuladon por metastazo kaj provizis loke kun multoblaj kreskfaktoroj respektive. L-Selectin belongs to a family of divalent cation-dependent carbohydrate-binding glycoproteins or adhesion molecules. The L-Selectin molecule is composed of various domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. P-selectin and Congenital disorder of glycosylation type IIc · See more » Crizanlizumab.

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P-selectin–deficient (Selp −/−) mice bred with apolipoprotein E–deficient (Apoe −/−) mice or with low-density lipoprotein (LDL) receptor–deficient (Ldlr −/−) mice develop smaller atherosclerotic lesions than control mice. 15 – 18 Bone marrow transplantation experiments suggest that P-selectin on nonhematopoietic presumably endothelial cells contributes more to atherosclerosis than P-selectin on hematopoietic cells. 19 However, infusion of activated platelets initiates

Plasma Selectin (P-selectin), also known CD62P and GMP-140, is a cell adhesion molecule and a member of the Selectin family. It is found in granules in endothelial cells and activated platelets.

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P-selectin is a transmembrane protein present in the α granules of platelets and the Weibel-Palade bodies of endothelial cells. Following activation,

Format: 96-well plate with removable strips. Compatible samples: cell culture supernates, serum and Hrsg . von P. Langenscheidt . Wulffen , E. , Psychologie des Verbrechers . 9 : e éd . Paris 1908.

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines.

1 Image. Catalog # Availability Size / Price Qty. FAB6169F . Human E-Selectin/P 38 e-selectin Primary Antibodies: Thermo Fisher antibodies are validated for applications including western blotting, immunocytochemistry, flow cytometry, and chromatin immunoprecipitation. 1 reviews. Compare Anti-E-selectin Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more. 1990-08-01 P-selectin and Congenital disorder of glycosylation type IIc · See more » Crizanlizumab.

P- and E-selectin-independent migration of Tc1 cells into the inflamed skin was predominantly mediated by L-selectin. The three selectins, E-selectin (CD62E), L-selectin (CD62L) and P-selectin (CD62P), are related both structurally and functionally. They have been extensively studied due to their role in the inflammatory response and their potential use as therapeutic targets. E-selectin, also known as CD62 antigen-like family member E, endothelial-leukocyte adhesion molecule 1, or leukocyte-endothelial cell adhesion molecule 2, is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines.